PDF Ebook Origin of Cancers: Clinical Perspectives and Implications of a Stem-Cell Theory of Cancer: 154 (Cancer Treatment and Research), by Shi-Min
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Origin of Cancers: Clinical Perspectives and Implications of a Stem-Cell Theory of Cancer: 154 (Cancer Treatment and Research), by Shi-Min
PDF Ebook Origin of Cancers: Clinical Perspectives and Implications of a Stem-Cell Theory of Cancer: 154 (Cancer Treatment and Research), by Shi-Min
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Précis This book is a treatise about the origin of cancers. I would like to convince readers that the basic tenets of the theory of a stem-cell origin of cancers also constitute a unified theory of cancer. Stem-cell origin of normal (and cancer) cells: Vitruvian version Every truth passes through three stages before it is recognized. In the first it is ridiculed, in the second, it is opposed, in the third, it is regarded as self-evident. – Arthur Schopenhauer v vi Preface Every person has a unique story to tell. My story is about cancer. Cancer touches the lives of countless people. Often enough, it leaves indelible tracks. Many lives have been lost; others are forever changed. For those who confront this deadly scourge, there is a sense of urgency, if not of desperation. For those who face im- nent death, life becomes even more precious and carries a special meaning. As an oncologist, I am touched daily by cancer. I feel its inception, evolution, and aft- math. It seems as though we are fighting an incessant war against cancer at the front line in the trenches. This is my story about cancer. Some people are terrific storytellers. Others have incredible tales to tell.
- Published on: 2010-07-20
- Released on: 2010-07-20
- Format: Kindle eBook
Review
From the reviews:
“This concise book is written for a broad audience of basic science and clinical researchers interested in cancer biology, as well as those interested in the identification and directed differentiation of adult and embryonic stem cells. The author’s clear writing style will appeal to young scientists and nonexperts who are interested in … cancer stem-cell theory. … is captivating, fascinating, instructive, and well written. … The book is fun to read. … This is a welcome addition to the literature on cancer biology.” (Bruce A. Fenderson, Doody’s Review Service, July, 2010) From the Back Cover
The theory of a stem-cell origin of cancer is neither ground breaking nor earth shattering. Many prominent investigators have established the foundation for this concept and performed the vital experiments to support its validity and merit. The purpose of this book is to illustrate how this theory may completely transform our current views and perspectives about cancer. It is anticipated that the variety of ramifications of a stem-cell origin of cancers will be embraced by the medical research community to bring new treatment modalities to the cancer patient.
"The stem-cell theory of cancer has significant biologic and clinical consequences. Though components remain open to debate the fundamental observations are grounded in scientific experimentation. This text explains the conceptual aspects of cancer stem cells with an emphasis on the implications for our patients."
- Steven T. Rosen, M.D.
Series Editor
Most helpful customer reviews
2 of 2 people found the following review helpful.
Possibly a landmark book!
By Camber
This book is brilliant and outstanding. Using exceptionally lucid and engaging writing, the author, Shi-Ming Tu, builds a convincing case for a 'unified theory of the origin of cancers' on the basis of both scientific arguments and experimental and clinical data. The fundamental idea is that cancers arise from stem cells or stem-like cells which inherently have the capacity to display malignant characteristics such as dormancy, self-renewal, drug resistance, immunoresistance, heterogeneity, lack of differentiation, aneuploidy, telomerase activation, angiogenesis, hypoxia, invasion, and metastasis. Manifestation of the malignant phenotype is then determined by factors such as the specifics of the particular stem cell (eg, its position in a stem cell hierarchy), crucial mutations (which may be only a small subset of all mutations found in cancers), interactions with the microenvironmental niche, and effects of selection through therapy. Thus, aspects of developmental biology come strongly into play.
Even if the author's stem cell hypothesis ultimately proves to not be a preferred model, this book is still packed with thought-provoking and valuable insights, and I therefore very highly recommend it to clinicians and researchers, as well as patients and caregivers who have sufficient background to read medical literature.
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